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Acute responsivity of the serotonergic system to S-citalopram and positive emotionality : the moderating role of the 5-HTTLPR

Wielpuetz, Catrin ; Kuepper, Yvonne ; Grant, Phillip ; Aisha, J ; Munk, L. ; Hennig, Juergen

Originalveröffentlichung: (2013) Frontiers in Human Neuroscience 7:486 doi:10.3389/fnhum.2013.00486
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URN: urn:nbn:de:hebis:26-opus-104232

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Freie Schlagwörter (Englisch): S-citalopram , 5-HTTLPR , positive emotionality ,serotonin , neuroendocrine challenge test
Sammlung: Open Access - Publikationsfonds
Universität Justus-Liebig-Universität Gießen
Fachgebiet: Psychologie
DDC-Sachgruppe: Psychologie
Dokumentart: Aufsatz
Sprache: Englisch
Erstellungsjahr: 2013
Publikationsdatum: 06.12.2013
Kurzfassung auf Englisch: According to the idea that the central serotonergic system has a modulatory function
on behavior and personality in general, we aimed to highlight its association to
habitual positive emotionality. In a placebo-controlled double-blind and randomized
cross-over neuroendocrine challenge design (n = 72 healthy males) we investigated the association
of the central serotonergic responsivity, 5-HTTLPR-genotype as well as their combined effects on
positive emotionality. Regression analyses revealed an involvement of the serotonergic system in
positive emotionality. There was, however, no direct association between positive emotionality and
cortisol responses to S-citalopram; rather
5-HTTLPR-genotype showed an association (p < 0.05). That is, positive emotionality scores
increased with the number of s-alleles carried by the individuals. Most notable was the
moderating role of 5-HTTLPR-genotype (p < 0.05) on the association between acute serotonergic
responsivity and positive emotionality. Indeed, this association was only found in
ss-homozygotes, in which the acute responsivity of the serotonergic system additionally
seems to contribute to the level of positive emotionality (r = 0.70, p < 0.05). The findings
correspond to previous research demonstrating that the 5-HTTLPR is not only involved in the
negative-emotional aspects of behavior and temperament, but is associated, moreover, with positive
affectivity—supporting the assumption of its valence-neutrality. In addition, our data are in line
with the idea of possible influences of the 5-HTTLPR-genotype on early neuronal development. They
also indicate the need for further studies in order to clearly elucidate the role of the
serotonergic system and its
subcomponents in the regulation of positive emotionality.
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