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Carnitine supplementation to obese Zucker rats prevents obesity-induced type II to type I muscle fiber transition and favors an oxidative phenotype of skeletal muscle

Couturier, Aline ; Mooren, Frank-Christoph ; Ringseis, Robert ; Krüger, Karsten ; Most, Erika ; Eder, Klaus


Originalveröffentlichung: (2013) Nutrition & Metabolism 10(1):48 doi:10.1186/1743-7075-10-48
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URN: urn:nbn:de:hebis:26-opus-104193
URL: http://geb.uni-giessen.de/geb/volltexte/2013/10419/

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Freie Schlagwörter (Englisch): Carnitine , Zucker rat , Muscle fiber transition , Type I fiber , Oxidative capacity , Fatty acid oxidation
Sammlung: Open Access - Publikationsfonds
Universität Justus-Liebig-Universität Gießen
Fachgebiet: Agrarwissenschaften, Ökotrophologie und Umweltmanagement fachübergreifend
DDC-Sachgruppe: Medizin
Dokumentart: Aufsatz
Sprache: Englisch
Erstellungsjahr: 2013
Publikationsdatum: 06.12.2013
Kurzfassung auf Englisch: Background: In the present study, we tested the hypothesis that carnitine supplementation counteracts obesityinduced
muscle fiber transition from type I to type II.
Methods: 24 obese Zucker rats were randomly divided into two groups of 12 rats each (obese control, obese
carnitine) and 12 lean Zucker rats were selected for lean control group. A control diet was given to both control
groups and a carnitine supplemented diet (3 g/kg diet) was given to obese carnitine group for 4 wk. Components
of the muscle fiber transformation in skeletal muscle were examined.
Results: The plasma level of carnitine were lower in the obese control group compared to the lean control group
and higher in the obese carnitine group than in the other groups (P < 0.05). Plasma concentrations of triglycerides
and non-esterified fatty acids were increased in obese animals compared to lean animals and the obese carnitine
group had lower level compared to the obese control group (P < 0.05). The obese carnitine group had an increased
number of type I muscle fibers and higher mRNA levels of type I fiber-specific myosin heavy chain, regulators of
muscle fiber transition and of genes involved in carnitine uptake, fatty acid transport, β-oxidation, angiogenesis,
tricarboxylic acid cycle and thermo genesis in M. rectus femoris compared to the other groups (P < 0.05).
Conclusion: The results demonstrate that carnitine supplementation to obese Zucker a rat counteracts the obesityinduced
muscle fiber transition and restores the muscle oxidative metabolic phenotype. Carnitine supplementation
is supposed to be beneficial for the treatment of elevated levels of plasma lipids during obesity or diabetes.
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