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Ion transport by pulmonary epithelia

Hollenhorst, Monika I. ; Richter, Katrin ; Fronius, Martin

Originalveröffentlichung: (2011) Journal of Biomedicine and Biotechnology, Article ID 174306 doi:10.1155/2011/174306
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URN: urn:nbn:de:hebis:26-opus-86105

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Freie Schlagwörter (Englisch): pulmonary epithelia , ion transport proteins , fluid layer viscosity , volume regulation , air-breathing vertebrates
Sammlung: Open Access - Publikationsfonds
Universität Justus-Liebig-Universität Gießen
Institut: Institute of Animal Physiology
Fachgebiet: Biologie
DDC-Sachgruppe: Tiere (Zoologie)
Dokumentart: Aufsatz
Sprache: Englisch
Erstellungsjahr: 2011
Publikationsdatum: 14.02.2012
Kurzfassung auf Englisch: The lung surface of air-breathing vertebrates is formed by a continuous epithelium that is covered by a fluid layer. In the airways, this epitheliumis largely pseudostratified consisting of diverse cell types such as ciliated cells, goblet cells, and undifferentiated basal cells, whereas the alveolar epitheliumconsists of alveolar type I and alveolar type II cells. Regulation and maintenance of the volume and viscosity of the fluid layer covering the epithelium is one of the most important functions of the epithelial barrier that forms the outer surface area of the lungs. Therefore, the epithelial cells are equipped with a wide variety of ion transport proteins, among which Na(+), Cl(-), and K(+) channels have been identified to play a role in the regulation of the fluid layer. Malfunctions of pulmonary epithelial ion transport processes and, thus, impairment of the liquid balance in our lungs is associated with severe diseases, such as cystic fibrosis and pulmonary oedema. Due to the important role of pulmonary epithelial ion transport processes for proper lung function, the present paper summarizes the recent findings about composition, function, and ion transport properties of the airway epithelium as well as of the alveolar epithelium.
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