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Identification and role of regulatory non-coding RNAs in Listeria monocytogenes

Izar, Benjamin ; Mraheil, Mobarak Abu ; Hain, Torsten

Originalveröffentlichung: (2011) International Journal of Molecular Sciences, 12(8), 5070-5079 doi:10.3390/ijms12085070
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URN: urn:nbn:de:hebis:26-opus-83356

Freie Schlagwörter (Englisch): regulatory RNA , Listeria monocytogenes , RNA interference , whole genome tiling arrays , infection
Sammlung: Open Access - Publikationsfonds
Universität Justus-Liebig-Universit√§t Gie√üen
Institut: Institute of Medical Microbiology
Fachgebiet: Medizin
DDC-Sachgruppe: Medizin
Dokumentart: Aufsatz
Sprache: Englisch
Erstellungsjahr: 2011
Publikationsdatum: 02.09.2011
Kurzfassung auf Englisch: Bacterial regulatory non-coding RNAs control numerous mRNA targets that direct a plethora of biological processes, such as the adaption to environmental changes, growth and virulence. Recently developed high-throughput techniques, such as genomic tiling arrays and RNA-Seq have allowed investigating prokaryotic cis- and trans-acting regulatory RNAs, including sRNAs, asRNAs, untranslated regions (UTR) and riboswitches. As a result, we obtained a more comprehensive view on the complexity and plasticity of the prokaryotic genome biology. Listeria monocytogenes was utilized as a model system for intracellular pathogenic bacteria in several studies, which revealed the presence of about 180 regulatory RNAs in the listerial genome. A regulatory role of non-coding RNAs in survival, virulence and adaptation mechanisms of L. monocytogenes was confirmed in subsequent experiments, thus, providing insight into a multifaceted modulatory function of RNA/mRNA interference. In this review, we discuss the identification of regulatory RNAs by high-throughput techniques and in their functional role in L. monocytogenes.
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