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Bacterial Outer Membrane Vesicles (OMVs)-based Dual Vaccine for Influenza A H1N1 Virus and MERS-CoV

Shehata, Mahmoud M. ; Mostafa, Ahmed ; Teubner, Lisa ; Mahmoud, Sara H. ; Kandeil, Ahmed ; Elshesheny, Rabeh ; Boubak, Thamer A. ; Frantz, Renate ; La Pietra, Luigi ; Pleschka, Stephan ; Osman, Ahmed ; Kayali, Ghazi ; Chakraborty, Trinad ; Ali, Mohamed A. ; Mraheil, Mobarak Abu

Originalveröffentlichung: (2019) Vaccines (Basel) 7(2):46 doi: 10.3390/vaccines7020046
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URN: urn:nbn:de:hebis:26-opus-157463

Freie Schlagwörter (Englisch): OMVs , influenza vaccine , MERS-CoV , H1N1pdm
Sammlung: Open Access - Publikationsfonds
Universität Justus-Liebig-Universit√§t Gie√üen
Institut: Institute of Medical Microbiology
Fachgebiet: Medizin
DDC-Sachgruppe: Medizin
Dokumentart: Aufsatz
Sprache: Englisch
Erstellungsjahr: 2019
Publikationsdatum: 01.12.2020
Kurzfassung auf Englisch: Vaccination is the most functional medical intervention to prophylactically control severe diseases caused by human-to-human or animal-to-human transmissible viral pathogens. Annually, seasonal influenza epidemics attack human populations leading to 290-650 thousand deaths/year worldwide. Recently, a novel Middle East Respiratory Syndrome Coronavirus emerged. Together, those two viruses present a significant public health burden in areas where they circulate. Herein, we generated a bacterial outer membrane vesicles (OMVs)-based vaccine presenting the antigenic stable chimeric fusion protein of the H1-type haemagglutinin (HA) of the pandemic influenza A virus (H1N1) strain from 2009 (H1N1pdm09) and the receptor binding domain (RBD) of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (OMVs-H1/RBD). Our results showed that the chimeric antigen could induce specific neutralizing antibodies against both strains leading to protection of immunized mice against H1N1pdm09 and efficient neutralization of MERS-CoV. This study demonstrate that OMVs-based vaccines presenting viral antigens provide a safe and reliable approach to protect against two different viral infections.
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