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Cone-Mediated Function Correlates to Altered Foveal Morphology in Preterm-Born Children at School Age

Bowl, Wadim ; Raoof, Sinan ; Lorenz, Birgit ; Holve, Kerstin ; Schweinfurth, Silke ; Stieger, Knut ; Andrassi-Darida, Monika


Originalveröffentlichung: (2019) Investigative Ophthalmology & Visual Science 60(5):1614-1620 doi: 10.1167/iovs.18-24892
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URN: urn:nbn:de:hebis:26-opus-152377
URL: http://geb.uni-giessen.de/geb/volltexte/2020/15237/


Freie Schlagwörter (Englisch): chromatic pupillometry , two-color perimetry , optical coherence tomography , prematurity , retinopathy of prematurity
Sammlung: Open Access - Publikationsfonds
Universität Justus-Liebig-Universit√§t Gie√üen
Institut: Department of Ophthalmology
Fachgebiet: Medizin
DDC-Sachgruppe: Medizin
Dokumentart: Aufsatz
Sprache: Englisch
Erstellungsjahr: 2019
Publikationsdatum: 01.07.2020
Kurzfassung auf Englisch: Purpose: To correlate cone- and rod-mediated function with morphology of the macula in preterm-born children without and with spontaneously regressed retinopathy of prematurity (ROP). Methods: We performed spectral-domain optical coherence tomography (SD-OCT) single scans in the macular center of preterm-born children aged 6 to 12 years (mean +/- SD, 7.4 +/- 1.8) without ROP (noROP; n = 59) and with spontaneously regressed ROP (srROP; n = 34), documented with wide-angle digital imaging during routine screening for acute ROP, and compared the data from 14 age-matched term-born children. SD-OCT data were compared to functional cone- and rod-mediated results of scotopic and photopic chromatic pupillometry (cP) and two-color fundus-controlled perimetry (2C-FCP). Results: SD-OCT showed a shallowed foveal pit with significantly reduced outer nuclear layer to inner retinal layer ratio, indicating macular developmental arrest (MDA). MDA was present in 44% of the srROP and 27% of the noROP children. Pupil reaction to photopic red stimuli on blue background showed significantly lower values in all preterm-born children with MDA. In accordance, photopic light increment sensitivity (LIS) to red stimuli in the foveal center on the 2C-FCP was also significantly reduced in children with MDA. Under scotopic conditions, no significant differences were apparent in both pupil reaction with cP and LIS with 2C-FCP. Conclusions: Both objective pupillary response to cone-mediated photopic red stimuli and subjective central cone-mediated results in fundus-controlled perimetry were reduced in preterm-born children with MDA. MDA was present in a significant number of patients with srROP, but also without ROP.
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