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Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice

Reutzel, Martina ; Grewal, Rekha ; Silaidos, Carmina ; Zotzel, Jens ; Marx, Stefan ; Tretzel, Joachim ; Eckert, Gunter P.


Originalveröffentlichung: (2018) Oxidative Medicine and Cellular Longevity 2018, Article ID 4070935, doi: 10.1155/2018/4070935
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URN: urn:nbn:de:hebis:26-opus-151857
URL: http://geb.uni-giessen.de/geb/volltexte/2020/15185/


Sammlung: Open Access - Publikationsfonds
Universität Justus-Liebig-Universit√§t Gie√üen
Institut: Institute of Nutritional Sciences, Laboratory for Nutrition in Prevention and Therapy
Fachgebiet: Haushalts- und Ern√§hrungswissenschaften - √Ėkotrophologie
DDC-Sachgruppe: Medizin
Dokumentart: Aufsatz
Sprache: Englisch
Erstellungsjahr: 2018
Publikationsdatum: 03.06.2020
Kurzfassung auf Englisch: Aging represents a major risk factor for developing neurodegenerative diseases such as Alzheimer¬īs disease (AD). As components of the Mediterranean diet, olive polyphenols may play a crucial role in the prevention of AD. Since mitochondrial dysfunction acts as a final pathway in both brain aging and AD, respectively, the effects of a mixture of highly purified olive secoiridoids were tested on cognition and ATP levels in a commonly used mouse model for brain aging. Over 6 months, female NMRI mice (12 months of age) were fed with a blend containing highly purified olive secoiridoids (POS) including oleuropein, hydroxytyrosol and oleurosid standardized for 50 mg oleuropein/kg diet (equivalent to 13.75 mg POS/kg b.w.) or the study diet without POS as control. Mice aged 3 months served as young controls. Behavioral tests showed deficits in cognition in aged mice. Levels of ATP and mRNA levels of NADH-reductase, cytochrome-c-oxidase, and citrate synthase were significantly reduced in the brains of aged mice indicating mitochondrial dysfunction. Moreover, gene expression of Sirt1, CREB, Gap43, and GPx-1 was significantly reduced in the brain tissue of aged mice. POS-fed mice showed improved spatial working memory. Furthermore, POS restored brain ATP levels in aged mice which were significantly increased. Our results show that a diet rich in purified olive polyphenols has positive long-term effects on cognition and energy metabolism in the brain of aged mice.
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