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Transcript profiling in the liver of early-lactating dairy cows fed conjugated linoleic acid

Ringseis, Robert ; Windisch, Wilhelm ; Eder, Klaus


Originalveröffentlichung: (2016) Genomics Data 10(2016):101-103 doi: 10.1016/j.gdata.2016.10.004
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URN: urn:nbn:de:hebis:26-opus-128469
URL: http://geb.uni-giessen.de/geb/volltexte/2017/12846/

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Sammlung: Open Access - Publikationsfonds
Universität Justus-Liebig-Universität Gießen
Institut: Institute of Animal Nutrition and Nutrition Physiology
Fachgebiet: Haushalts- und Ernährungswissenschaften - Ökotrophologie
DDC-Sachgruppe: Landwirtschaft
Dokumentart: Aufsatz
Sprache: Englisch
Erstellungsjahr: 2016
Publikationsdatum: 24.05.2017
Kurzfassung auf Englisch: In the present study, transcript profiling was carried out in liver biopsies from high-yielding dairy cows at week 5 of lactation in order to identify genes and pathways regulated by feeding rumen-protected conjugated linoleic acid (CLA) during the transition period. Analysis of a bovine whole genome microarray revealed a total number of 130 annotated differentially expressed genes (DEGs) in the liver between cows of the CLA group and the control group (filter: P < 0.05 and fold change (FC) = 1.3 or =- 1.3). The number of DEGs in the liver being up-regulated was markedly higher than that being down-regulated (86 vs. 44). Gene set enrichment analysis revealed that the most enriched biological processes and molecular functions assigned to the 86 up-regulated genes were S-methyltransferase activity, ribonucleoprotein complex biogenesis, homocysteine S-methyltransferase activity, methionine biosynthetic process and spliceosome assembly, while the most enriched biological processes and molecular functions assigned to the 44 down-regulated genes were exopeptidase activity, cytokinesis after mitosis, cytokinesis during cell cycle, protein serine/threonine kinase activity and cytokinesis. The microarray dataset from this study has been deposited in NCBI´s Gene Expression Omnibus under the accession number GSE87391.
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