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Magnesium-containing mixed coatings on zirconia for dental implants: mechanical characterization and in vitro behavior

Pardun, Karoline ; Treccani, Laura ; Volkmann, Eike ; Streckbein, Philipp ; Heiss, Christian ; Gerlach, Juergen W. ; Maendl, Stephan ; Rezwan, Kurosch


Originalveröffentlichung: (2015) Journal of Biomaterials Applications 30(1): 104–118; DOI: 10.1177/0885328215572428
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URN: urn:nbn:de:hebis:26-opus-124574
URL: http://geb.uni-giessen.de/geb/volltexte/2017/12457/

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Freie Schlagwörter (Englisch): zirconia , calcium phosphate , magnesium , bioactivity , implant coating
Sammlung: Allianz-/Nationallizenzen / Artikel
Universität Justus-Liebig-Universität Gießen
Institut: Department of Cranio-Maxillo-Facial Surgery
Fachgebiet: Medizin
DDC-Sachgruppe: Medizin
Dokumentart: Aufsatz
Sprache: Englisch
Erstellungsjahr: 2015
Publikationsdatum: 25.01.2017
Kurzfassung auf Englisch: An important challenge in the field of dental and orthopedic implantology is the preparation of implant coatings with bioactive functions that feature a high mechanical stability and at the same time mimic structural and compositional properties of native bone for a better bone ingrowth. This study investigates the influence of magnesium addition to zirconia-calcium phosphate coatings. The mixed coatings were prepared with varying additions of either magnesium oxide or magnesium fluoride to yttria-stabilized zirconia and hydroxyapatite. The coatings were deposited on zirconia discs and screw implants by wet powder spraying. Microstructure studies confirm a porous coating with similar roughness and firm adhesion not hampered by the coating composition. The coating morphology, mechanical flexural strength and calcium dissolution showed a magnesium content-dependent effect. Moreover, the in vitro results obtained with human osteoblasts reveal an improved biological performance caused by the presence of Mg2+ ions. The magnesiumcontaining coatings exhibited better cell proliferation and differentiation in comparison to pure zirconia-calcium phosphate coatings. In conclusion, these results demonstrate that magnesium addition increases the bioactivity potential of zirconia-calcium phosphate coatings and is thus a highly suitable candidate for bone implant coatings.
Lizenz: Allianz- / Nationallizenz