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Effects of acute endurance exercise on plasma protein profiles of endurance-trained and untrained individuals over time

Schild, Marius ; Eichner, Gerrit ; Beiter, Thomas ; Zügel, Martina ; Krumholz-Wagner, Ilke ; Hudemann, Jens ; Pilat, Christian ; Krüger, Karsten ; Niess, Andreas M. ; Steinacker, Jürgen M. ; Mooren, Frank C.

Originalveröffentlichung: (2016) Mediators of Inflammation 2016:Article ID 4851935 doi: 10.1155/2016/4851935
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URN: urn:nbn:de:hebis:26-opus-123161

Sammlung: Open Access - Publikationsfonds
Universität Justus-Liebig-Universität Gießen
Institut: Department of Sports Medicine
Fachgebiet: Sportwissenschaft
DDC-Sachgruppe: Medizin
Dokumentart: Aufsatz
Sprache: Englisch
Erstellungsjahr: 2016
Publikationsdatum: 28.10.2016
Kurzfassung auf Englisch: Acute physical exercise and repeated exercise stimuli affect whole-body metabolic and immunologic homeostasis. The aim of this study was to determine plasma protein profiles of trained (EET, n=19) and untrained (SED, n=17) individuals at rest and in response to an acute bout of endurance exercise. Participants completed a bicycle exercise test at an intensity corresponding to 80% of their VO2max. Plasma samples were taken before, directly after, and three hours after exercise and analyzed using multiplex immunoassays. Seventy-eight plasma variables were included in the final analysis. Twenty-nine variables displayed significant acute exercise effects in both groups. Seven proteins differed between groups, without being affected by acute exercise. Among these A2Macro and IL-5 were higher in EET individuals while leptin showed elevated levels in SED individuals. Fifteen variables revealed group and time differences with elevated levels for IL-3, IL-7, IL-10, and TNFR2 in EET individuals. An interaction effect could be observed for nine variables including IL-6, MMP-2, MMP-3, and muscle damage markers. The proteins that differ between groups indicate a long-term exercise effect on plasma protein concentrations. These findings might be of importance in the development of exercise-based strategies in the prevention and therapy of chronic metabolic and inflammatory diseases and for training monitoring.
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